seminario Bezhan Chankvetadze

Seminario di Bezhan Chankvetadze

Lunedì, 15 Novembre, 2021
Alessandra Gentili è lieta di invitarvi al seminario di dipartimento:

Development and current trends in using polysaccharide-based chiral selectors for separation of enantiomers in liquid-phase

di Bezhan Chankvetadze
Institute of Physical and Analytical Chemistry, School of Exact and Natural Sciences, Tbilisi State University (Georgia)


Polysaccharide derivatives represent one of the most successful group of chiral selectors for separation of enantiomers in liquid-phase techniques, such as high-performance liquid chromatography (HPLC), supercritical fluid chromatography (SFC), nano-liquid chromatography (nano-LC) and capillary electrochromatography (CEC). A chiral stationary phase (CSP) has to meet certain requirements in very competitive environment in order to be widely accepted and applied. The major requirements are universality not only from the viewpoint of coverage of various chiral analytes but also from the viewpoint of applicability in various abovementioned modes and compatibility with various type of mobile phases, stability, robustness, versatility and availability. This presentation summarizes the concept we applied for development of novel polysaccharide-based chiral selectors in 1990s and our current attempts in order to implement chemo- and enantio-selectivity in the same CSP, to create stable and robust CSPs by covalent attachment of a chiral selector onto silica and creating CSPs with favorable kinetic properties by using superficially porous silica. In the presentation our strategy for obtaining extremely high separation factor (alfa > 100) in HPLC separation of enantiomers, as well as baseline separation of enantiomers on a few-second timescale will be also demonstrated.

Il seminario si terrà in Sala Parravano mercoledì 24 novembre dalle ore 14.30.

Potrà essere seguiti in presenza (il numero dei posti disponibili in Sala Parravano è limitato a 32 dalle misure di prevenzione e protezione dal contagio da COVID-19 indicate nei DPCM del 26/04/2020 e successivi e alle misure aggiuntive indicate dall'Ateneo.

È possibile partecipare da remoto su piattaforma Google Meet:


Bezhan Chankvetadze photo Bezhan Chankvetadze

Bezhan Chankvetadze is Full Professor for Physical Chemistry and director of the Institute of Physical and Analytical Chemistry at the Tbilisi State University in Tbilisi, Georgia. Between 1991-2005 Chankvetadze held research and teaching positions at the Institute of Pharmaceutical and Medicinal Chemistry, University of Münster, Germany and at the Department of Applied Chemistry, Graduate School of Engineering, Nagoya University, Japan.

Chankvetadze has published over 250 research papers in peer reviewed journals, over 30 review papers and book chapters and holds several patents of the former Soviet Union, USA, Germany and Japan.

B. Chankvetadze has published one monograph (Capillary Electrophoresis in Chiral Analysis, Wiley&Sons, Chichester, UK, 1997), co-authored one book (Quantitative Determination of Antiepileptic Drugs in Biological Fluids, Tbilisi University Press, Tbilisi, Georgia, 1993) and edited one multiautored book (Chiral Separations, Elsevier Science, 2001). He has edited and co-edited many special issues of the journals J. Chromatogr. A, Electrophoresis, J. Pharm. Biomed. Anal., and Journal Separation Science on various topics of separation science.Chankvetadze has given over 300 presentations as plenary, invited or oral speaker on the international conferences, as well as in industry and academia in fields of chirality, electromigration techniques and separation science.

B. Chankvetadze has developed and commercialized in co-operation various companies more than 10 polysaccharide-based chiral stationary phase for liquid-phase separation of enantiomers. He is the Editor of the Journal of Pharmaceutical and Biomedical Analysis (Elsevier, Amsterdam, Netherlands) and a member of the editorial boards of Electrophoresis (Wiley-VCH), Journal of Chromatography A (Elsevier), Journal of Chromatography O (Elsevier), Journal of Separation Science (Wiley-VCH), Chirality (Wiley), Acta Chromatographica and several other international journals.

Chankvetadze is the recipient of “Journal of Chromatography Top Cited Article Awards” in 2005, 2006 and 2010, “2006 Belgian Society of Pharmaceutical Science Award of Recognition”, “The Scientist of the Year 2016” award of the Shota Rustaveli National Science Foundation (Georgia), and Csaba Horvath Memorial Award of the Hungarian Chemical Society and Connecticut Separation Science Council (USA) (2017).

Prof. B. Chankvetadze is Full Member of the Georgian National Academy of Sciences.

© Università degli Studi di Roma "La Sapienza" - Piazzale Aldo Moro 5, 00185 Roma