Synthesis of new non peptidic inhibitors of HIV Protease antivirals bearing heteroaromatic fragments and evaluation of their "repurposing" as antitumor compounds

Line of research
The research activity concerns the synthesis of molecules bearing an heteroaromatic fragment on an hydroxyethylamine core, starting from enantiopure epoxides, easily available from chiral pool and their evaluation as non peptidic inhibitors of HIV Protease (native or mutate), together with their repurposing as antitumor compounds. Regioselective oxiranyl ringopening reactions and selective functionalization of amine groups are studied. Tests of their in vitro and ex vivo (in cells) activity are made in collaboration with the University of Trieste and University of Basilicata.

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