Porphyrazine macrocycles: synthesis, chemico-physical characterization and potential applications in the biochemical/biomedical field Line of research Design, synthesis, general chemico-physical characterization, and study of the photophysical and photochemical properties of novel classes of mono- and multimetallic porphyrazine macrocycles, having innovative structural features, suitable for potential applications in the biochemical/biomedical field. Some of the studied porphyrazines are able to act as photosensitizers for the generation of singlet oxygen, the cytotoxic agent in photodynamic therapy (PDT) and may have potentialities to be used for a multimodal anticancer curative modality. Linee Ricerca_Donzello.pdf Staff Supervisor: Maria Pia DonzelloDepartment staff: Ida PettitiMaria Luisa AstolfiElisa ViolaUniversity staff: Mannina Luisa (Dip. CTF)Stranges Stefano (Dip. CTF)Ciogli Alessia (Dip.CTF) Publications Tetra-2,3-Pyrazinoporphyrazines with Externally Appended Pyridine Rings 22 Synthesis, Physicochemical and Photoactivity Studies on In(III) Mono- and Heteropentanuclear ComplexesBis(CBT)palladium(II) Derivatives (CBT = m-carborane-1-thiolate): Synthesis, Molecular Structure, and Physicochemical Properties of cis-[(bipy)Pd(CBT)2] and trans-[(py)2Pd(CBT)2]Octakis(2-pyridyl)porphyrazine and Its Neutral Metal Derivatives: UV–Visible Spectral, Electrochemical, and Photoactivity StudiesPalladium(II) and Platinum(II) Mononuclear Complexes and Tendency to Undergo Dehydrogenation of the Multiple N-Donor Ligand Di-(2-pyridyl)dihydropyrazineCharacterization of tetrakis(thiadiazole)porphyrazine metal complexes by magnetic circular dichroism and magnetic circularly polarized luminescenceA Phthalocyanine-ortho-carborane conjugate for boron neutron capture therapy: synthesis, physicochemical properties, and in vitro testsTetra-2,3-pyrazinoporphyrazines with peripherally appended pyridine rings. 19. Pentanuclear octa(2-pyridyl)tetrapyrazinoporphyrazines carrying externally carboranthiolate groups: physicochemical properties and potentialities as anticancer drugsTetra-2,3-pyrazinoporphyrazines with peripherally appended pyridine rings. 20. Mono- and pentanuclear AlIII and GaIII complexes: synthesis and physicochemical and photoactivity studiesTetrapyrazinoporphyrazines and their metal derivatives. Part II: Electronic structure, electrochemical, spectral, photophysical and other application related propertiesPhotoactivity of new octacationic magnesium(II) and zinc(II) porphyrazines in a water solution and G-quadruplex binding ability of differently sized zinc(II) porphyrazines Collaborations National collaborations: Rizzoli Corrado (Dip di Scienze Chimiche, della Vita e della Sostenibilità Ambientale, Università di Parma) Manet Ilse (ISOF-CNR, Bologna) International collaborations: Kadish Karl M. (Dep of Chemistry, University of Houston, Texas USA)Stuizhin Pavel A. (Research Institute of Macroheterocycles, Ivanovo State University of Chemical Technology, Russian)Kunio Awaga (Research Center for Materials Science & Department of Chemistry, Nagoya University, Japan)Zimcik Petr (Faculty of Pharmacy in Hradec Kralove, Charles University, Prague, Czech Republic) Fundings and awards Fundings: Macrocicli tetrapirrolici di tipo porfirazinico: sintesi, caratterizzazione chimico-fisica e potenzialità applicative in ambito biomedico Progetti di Ricerca Medi 2022 - ResponsabileInnovative High Resolution Mass Spectrometry Based on Dual Fragmentation Process: a New Frontier for Structure Elucidation of Chemical Systems - Grandi Attrezzature - 2022 - ComponenteMacrocicli porfirazinici: progettazione, sintesi, caratterizzazione chimico-fisica e potenzialità applicative in ambito biomedico Progetti di Ricerca - Medi - 2021 - Responsabile Microfluidic viscometry, a valid tool to assist 3D Bioprinting of Aqueous Two-Phases Emulsions - Medie Attrezzature -2021 - Componente Macrocicli porfirazinici: Sintesi, caratterizzazione chimico-fisica e potenzialità di applicazione in campo biomedico Progetti di Ricerca - Medi - 2020- Responsabile Theme and ERC Theme: Life-Sciences chemistryERC: PE4_6 Chemical physicsPE5_9 Coordination chemistryPE5_14 Macromolecular chemistry Traineeship offer Area di ricerca: Inorganic chemistryAvailability: two positionsCourse of study (advised): Chemistry
