Novel bio and nanofabrication techniques for the synthesis of innovative materials for biotechnological applications Line of research The aim of this research is the design and production of biopolymeric, nano and microstructured materials, able to entrap bioactive molecules and genes in mammalian cell lines, plant cells and microbial cells or as carriers of industrial enzymes. The preparation of these materials is based on nanoprecipitation phenomena, achieved through innovative techniques such as patented methodologies within the research group (PCT Sapienza RM2004A000555) and flowfocusing microfluidic reactors. Staff Supervisor: Cleofe PalocciDepartment staff: Laura ChronopoulouUniversity staff: Bordi Federico (Dip. di Fisica)Pasqua Gabriella (Dip. di Biologia Ambientale)Stefano Lupi (Dip. di Fisica)Ombretta Turruziani (Dip. di Medicina molecolare)Giovanna Simonetti (Dip. di Sanità Pubblica e Malattie Infettive) Publications Chitosan-coated PLGA nanoparticles: a sustained drug release strategy for cell culturesAnti-Candida Biofilm Activity of Pterostilbene or Crude Extract from Non-Fermented Grape Pomace Entrapped in Biopolymeric NanoparticlesPLGA-based nanoparticles: effect of chitosan in the aggregate stabilization. A dielectric relaxation spectroscopy studyFunctional polymeric nanoparticles for dexamethasone loading and releasePLGA based particles as “drug reservoir” for antitumor drug delivery: characterization and cytotoxicity studiesStructure-activity relationships of Candida rugosa lipase immobilized on polylactic acid nanoparticles Collaborations National collaborations: Nocca Giuseppina (Università Cattolica del Sacro Cuore, Roma)Paradossi Gaio (Università degli Studi di Roma "Tor Vergata")Massimi Mara (Università degli Studi dell'Aquila)Diociaiuti Marco (Istituto Superiore di Sanità)Manuela Romagnoli (Università della Tuscia)Nadia Felli (Istituto Superiore di Sanità)International collaborations: Kamel Gihan (Helwan University, Egitto)Sub Reddy (University of Surrey, Guildford UK)Ulrich Schaffrath (RWTH Aachen University, Germania) Fundings and awards Fundings: Ateneo 2016 Ateneo 2019 Theme and ERC Theme: MaterialsERC: PE4_4 Surface science and nanostructuresPE5_6 New materials: oxides, alloys, composite, organic-inorganic hybrid, nanoparticlesPE5_10 Colloid chemistry Traineeship offer Area di ricerca: Industrial chemistryAvailability: one positionCourse of study (advised): ChemistryIndustrial chemistry
