Recent Advances in Asymmetric Iron Catalysis in Organic Synthesis
Andrea Lapi is pleased to invite to the seminar:
Recent Advances in Asymmetric Iron Catalysis in Organic Synthesis
Thierry Ollevier
Département de chimie, Université Laval Québec, Canada
The seminar will be held in Parravano hall, first floor - S. Cannizzaro building CU014, on Tuesday 6th June at 2.30 pm.
It can be followed in streaming on Google meet: tkg-xmjk-dxj.
Abstract
The objective of our research program is the development of new synthetic methods, with emphasis on catalytic and enantioselective procedures for the simple preparation of molecules. Our program targets major advancements in green chemistry, which is an area of major strategic and industrial importance. Iron-derived Lewis acids have been developed as green catalysts for asymmetric synthesis. Chiral iron complexes have been employed in selected asymmetric C–C, C–N, and C–S bond-forming reactions, such as the Mukaiyama aldol, epoxide opening, thia-Michael and Diels-Alder reactions. [1] As we focused our interest on the ligand design of 2,2′-bipydiols, both steric and electronic properties of these ligands were tackled. [2]
The synthesis of a bulky (S,S)-2,2′-bipyridine-⍺,⍺′-1-Adamantyl-diol ligand was developed and its synthetic value was demonstrated in selected Fe(II/III)-catalyzed benchmark reactions in terms of chiral induction when compared to other 2,2′-bipydiol analogs. Also, we have been the first to develop an efficient chiral C2- symmetric 2,2′-bipydiol ligand possessing a CF3 group in the ⍺,⍺′-positions. These results contribute to the development of iron catalysis for asymmetric synthesis.
References
- (a) Li, M.; Carreras, V.; Jalba, A.; Ollevier, T. Org. Lett. 2018, 20, 995. (b) Lauzon, S.; Keipour, H.; Gandon, V.; Ollevier, T. Org. Lett. 2017, 19, 6324. (c) Ollevier, T.; Plancq., B. Chem. Commun. 2012, 48, 2289.
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(a) Lauzon, S.; Schouwey, L.; Ollevier, T. Org. Lett. 2022, 24, 1116. (b) Lauzon, S.; Caron, L.; Ollevier, T. Org. Chem. Front. 2021, 8, 2242. (c) Lauzon, S.; Ollevier, T. Chem. Commun. 2021, 57, 11025. (d) Lauzon, S.; Ollevier, T. Chem. Sci. 2022, 13, 10985.
Biographic sketch
Thierry Ollevier was born in Brussels and obtained his B.Sc. (1991) and Ph.D. (1997) at the Université of Namur (Belgium), and was post doctorate fellow at the Université catholique de Louvain (Belgium), under I. E. Markó (1997), NATO postdoctorate fellow at Stanford University under B. M. Trost (1998–2000), then post doctorate fellow at the Université de Montréal under A. B. Charette (2000–2001). After an Assistant Professor appointment (2001) at Université Laval (Québec, Canada), he became Associate (2006) and is currently Full Professor. Current research in his group aims at designing novel catalysts, developing catalytic reactions and applying these methods to chemical synthesis. He is active in the areas of iron catalysis, ligand design, asymmetric catalysis, fluorine chemistry, diazo and diazirine chemistry, flow chemistry, and bismuth chemistry. He has published more than 85 papers and 35 encyclopedia articles and book chapters.
He has served as an Associate Editor of RSC Advances from 2015 to 2022 and was admitted as a Fellow of the Royal Society of Chemistry (2016). After 5 years served as Advisory Board member of SynOpen, he has been appointed as Editor-in-Chief of SynOpen in 2023.
Prizes and honors
- Fellow of the Royal Society of Chemistry (UK) (2015–2022)
- “Professor of the Month” awarded by Silicycle, Québec, February 2014
- “Best Young Presenter Prize” awarded by the Australian Journal of Chemistry at the Eurasia12 meeting, Corfu, April 2012
- Professeur étoile (Teaching prize based on the students’ evaluations, Faculté des sciences et de génie, Université Laval, 2022-2017, 2014, 2013, 2011, 2010, 2004)
- Highlighted articles: Synfacts (9), ChemInform (14), journal covers (6)
- Member of the Commission de terminologie et de néologie de la chimie et des matériaux (Ministère de l’Économie, des Finances et de l’Industrie, Paris) (2010–)
- Prix Stas (Prize from the Belgian Royal Academy, 1997)
Publications and Conferences on Invitation
- 116 Publications (84 research articles, 30 encyclopedia articles, 2 conference proceedings)
- 1 Edited book, 4 book chapters, 1 patent
- 2573 Citations, h factor = 30 (Web of Science, 15 May 2023)
- 110 Conferences on invitation (scientific meetings: 21, univ. & industr. conf.: 89)