Ennio Tasciotti seminar
Luciano Galantini and Giulio Caracciolo (Dipartimento di Medicina Molecolare) are pleased to invite to the seminar:
Engineering the nano bio interface of biomimetic nanovescicles
Dr. Ennio Tasciotti, San Raffaele University, Rome
The seminar will be held in Parravano Hall , S. Cannizzaro building CU014, on 18th July at 11 am.
Abstract
Recent advances in the field of material science have shown that biomaterials and biomimeticapproaches can be employed to improve the functional properties of biomedical technologies. In particular, the seminar will focus on the design and development ofnanocarriers endowed with a biological identity to autologous biological entities (immune cells, exosomes, apoptotic bodies). All these approaches benefit from advantageous properties that make their functions superior to those of previous generations of nanoparticles.
The seminar will describe the molecular composition, the biochemistry of the nano-bio interface, the pharmacology and the interaction with the cells of the circulatory and immune system. Overall, this new class of nanovescicles showed improved circulation time, targeting, and drug delivery capabilities and promising therapeutic effects in preclinical models of inflammatory based pathologies (sepsis, auto-immune, cardiovascular, cancer). By creating innovative biomedical platforms able to better interact with the different cell populations of the surrounding microenvironment, it is possible to ameliorate the function of drug delivery nanoparticles, to improve the accumulation of a therapeutic payload at the target site, and to develop inherently therapeutic biomimetic nanovesicles.