Biological Fate studies of Nanocarries for drug delivery - Seminario di Sergio E. Moya, CIC biomaGUNE, Spain
Mauro Giustini is glad to invite you at the Departement seminar:
Biological Fate studies of Nanocarries for drug delivery: Degradation and stability of hybrid nanomaterials in biological environments, and formation of biocoronas
by Sergio E. Moya
CIC biomaGUNE, San Sebastian, Spain
Seminar will be held in Sala Parravano on July 1, 2021 at 11.00 a.m.
To partecipate remotely, please reach: https://meet.google.com/nee-pkbg-nhn.
Nanoformulations offer multiple advantages over conventional drug delivery, enhancing solubility, biocompatibility, and bioavailability of drugs. Following systemic delivery nanocarriers must deliver encapsulated drugs, usually through nanocarrier degradation. A premature degradation or the loss of the nanocarrier coating may prevent the delivery of the drug to the targeted tissue. Despite their importance, stability and degradation of nanocarriers in biological environments are seldom studied in literature.
In this presentation issues related to the biological fate and stability of nanocarriers in biological matrixes will be discussed: the interaction of the nanocarriers with proteins, the biodistribution of the nanocarriers, their biological fate, the kinetics of drug release in vitro/in vivo and the stability of the core and surface coating of the nanocarriers. In vitro, we will make use of Fluorescence Correlation Spectroscopy for studying nanocarriers stability, the fate of protein corona after translocation and the relation between surface chemistry, protein corona formation and the aggregation of nanocarriers intracellularly. In vivo, we will apply Positron Emission Tomography and Single Photon Emission Tomography to study the biodistribution of nanocarriers, the stability of surface coatings and nanocarrier dissolution in vivo, using advanced radiolabelling strategies.
Sergio E. Moya
Sergio E. Moya studied Chemistry at the National University of the South, Argentina.
He got a PhD in Physical Chemistry, Magna Cum Laude, working at the Max Planck Institute of Colloids and Interfaces, Golm, Germany under the supervision of Helmuth Moehwald and Edwin Donath.
He did his post doc at the College de France, in the group of Jean Marie Lehn and at the Nanoscience centre at the University of Cambridge, UK. After UK he worked as independent researcher at the Centre of Applied Chemistry in Mexico for 2 years. Since 2007 he is group leader at CIC biomaGUNE, a center of biomaterials located at San Sebastian, Spain. He has been Adjunct Faculty at Zhejiang University, China. He is the author of 230 papers in Material Science, Nanotechnology and Chemistry and he has coordinated several EU and international projects. His research interests cover the use of polyelectrolytes in nanofabrication, self assembly, hybrid materials, physical chemistry, nanomedicine, and fate of nanomaterials